Chang, M.; Wilson, C. J.; Karunatilleke, N. C.; Moselhy, M. H.; Karttunen, M.; Choy, W.-Y. Exploring the Conformational Landscape of the Neh4 and Neh5 Domains of Nrf2 Using Two Different Force Fields and Circular Dichroism. J. Chem. Theory Comput. 2021, 17 (5), 3145–3156.
Explored the structural dynamics of KEAP1 Cancer mutants and their mutagenic effect
Wilson, C. J.; Chang, M.; Karttunen, M.; Choy, W.-Y. KEAP1 Cancer Mutants: A Large-Scale Molecular Dynamics Study of Protein Stability. Int. J. Mol. Sci. 2021, 22 (10), 5408.
Elucidated the structural and dynamical properties of Nrf2 and evaluated the capabilities of Molecular dynamics simulations
Chang, Megan Nicole, "Elucidating the Structural and Dynamical Properties of the Intrinsically Disordered Protein Nrf2 Using Molecular Dynamics Simulations" (2021). Electronic Thesis and Dissertation Repository. 8293.
About
I have an interest in uncovering proteins' roles in biological processes while presenting it in an engaging and effective manner
I strive to make science captivating for audiences by finding the intersection between science and design
My background in computer science, structural biology, and statistical mechanics makes me a unique candidate
During my off-time I enjoy cross-stitching, fashion, and film
A few of my technical skills
Contact
Here are my socials
References
Intro: Image features use of 1U2N (De Guzman, R. N., Wojciak, J. M., Martinez-Yamout, M. A., Dyson, H. J., & Wright, P. E. (2005). CBP/p300 TAZ1 domain forms a structured scaffold for ligand binding. Biochemistry, 44(2), 490–497.) created with VMD (Humphrey, W., Dalke, A., & Schulten, K. (1996). VMD: visual molecular dynamics. Journal of molecular graphics, 14(1), 33–38.). Simulation is my own.
About: Image of 2FLU (Lo, S. C., Li, X., Henzl, M. T., Beamer, L. J., & Hannink, M. (2006). Structure of the Keap1: Nrf2 interface provides mechanistic insight into Nrf2 signaling. The EMBO journal, 25(15), 3605–3617.) created with PyMol (PyMOL. (2015). The PyMOL Molecular Graphics System, Version 2.0.).
References
Intro: Image features use of 1U2N (De Guzman, R. N., Wojciak, J. M., Martinez-Yamout, M. A., Dyson, H. J., & Wright, P. E. (2005). CBP/p300 TAZ1 domain forms a structured scaffold for ligand binding. Biochemistry, 44(2), 490–497.) created with VMD (Humphrey, W., Dalke, A., & Schulten, K. (1996). VMD: visual molecular dynamics. Journal of molecular graphics, 14(1), 33–38.). Simulation is my own.
About: Image of 2FLU (Lo, S. C., Li, X., Henzl, M. T., Beamer, L. J., & Hannink, M. (2006). Structure of the Keap1: Nrf2 interface provides mechanistic insight into Nrf2 signaling. The EMBO journal, 25(15), 3605–3617.) created with PyMol (PyMOL. (2015). The PyMOL Molecular Graphics System, Version 2.0.).
